Endometrium and Uterus

Studies include

• Assessment of Screening Modalities for Gynecologic Cancers

  A feasibility study to assess the use of alternative sampling techniques and molecular assays to detect endometrial and ovarian cancer

• Benign Reproductive Tissue Evaluation Study

  A study to investigate the association of risk factors with molecular changes in the ovaries and endometrium

• Bone Density and Cancer Risk: A Follow-Up Study of Women in the Fracture Intervention Trial (BFIT)

  A retrospective cohort study that uses data from the FIT clinical trial to evaluate how bone mineral density of the hip is related to subsequent cancer risk; including a nested case-cohort study of circulating sex steroid hormones in relation to breast, endometrial, ovarian, and colorectal cancer risk

• The DETECT Study – Discovery and Evaluation of Testing for Endometrial (Uterine) Cancer in Tampons

  DCEG investigators are partnering with the University of Alabama Birmingham to evaluate the acceptability and feasibility of self-sampling with vaginal tampons for detection of endometrial/uterine cancer n a racially-diverse population of women undergoing hysterectomy.

• Endometrial cancer risk factors & biomarkers for natural history & early detection: The Mayo Study

  A prospective cohort study to assess risk factors for endometrial cancer and its precursors and collect novel biospecimens using vaginal tampons and Tao brush for biomarker studies. This study is a collaboration between researchers at the NCI and the Mayo Clinic.

• Follow-up Studies of Women Evaluated and Treated for Infertility

  Retrospective cohort studies of women treated for infertility with ovulation-stimulating drugs to evaluate risk of breast and gynecologic cancers

• Ovarian and Endometrial Cancer Case-Control Study in Poland

  A study of common inherited variation associated with risk of ovarian cancer, carried out using data and biospeciments from a population-based case-control study of ovarian and endometrial cancer conducted among female residents of Warsaw and Lodz (Poland).

• Serum Sex Steroids and Their Metabolites in Relation to Ovarian and Endometrial Cancer

  A nested case-control study of endometrial and ovarian cancers assessing the roles of estrogens, estrogen metabolites, androgens, and androgen metabolites in the etiologies of these cancers

• Study of Endometrial Hyperplasia Progression

  The goal of the study is to define risks of progression for histological categories of endometrial hyperplasia, the precursor of typical forms of endometrial carcinoma, and to validate candidate molecular pathological prognostic markers to assess risk of subsequent carcinoma.