Nasopharyngeal Case-Control Study
Two case-control studies were conducted in Taiwan between 1991-1994 and 2010-2014. Together, these two studies included more than 2,000 NPC cases and more than 2,400 controls and were designed to examine the role of viral, environmental, and genetic factors associated with the development of nasopharyngeal carcinoma (NPC). Factors investigated include Epstein-Barr virus, diet, smoking, occupation, HLA, and other genetic polymorphisms. Histologically confirmed incident cases of nasopharyngeal cancer and two controls groups (hospital and community) were recruited. Participants completed an in-depth, in-person risk factor questionnaire that obtained information on adult and early life exposures. Blood and other specimens were collected from participants to allow for molecular assessment of various environmental and genetic factors of interest.