Nasopharyngeal Family Study
A family study is currently ongoing in Taiwan to elucidate genetic factors linked to the development of nasopharyngeal cancer (NPC). Approximately 350 multiplex families with two or more individuals affected with NPC have been identified and recruited into the study. Active clinic follow-up and passive follow-up via linkage to the national tumor registry is ongoing. Whole-exome sequencing was recently completed and evaluation of viral markers of risk that might be of clinical utility are under evaluation. A risk factor questionnaire is administered to all participants and blood, saliva and nasopharyngeal swabs is collected at study visits to allow us to examine the joint effects of genetic and environmental factors in the pathogenesis of NPC.