Ovary
DCEG researchers conduct studies on cancers of the ovary, also known as ovarian cancer. Most ovarian cancers are either epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or malignant germ cell tumors (cancer that begins in egg cells). Selected studies include:
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Benign Reproductive Tissue Evaluation Study
A study to investigate the association of risk factors with molecular changes in the ovaries and endometrium
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Bone Density and Cancer Risk: A Follow-Up Study of Women in the Fracture Intervention Trial (BFIT)
A retrospective cohort study that uses data from the FIT clinical trial to evaluate how bone mineral density of the hip is related to subsequent cancer risk; including a nested case-cohort study of circulating sex steroid hormones in relation to breast, endometrial, ovarian, and colorectal cancer risk
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Follow-up Studies of Women Evaluated and Treated for Infertility
Retrospective cohort studies of women treated for infertility with ovulation-stimulating drugs to evaluate risk of breast and gynecologic cancers
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Ovarian and Endometrial Cancer Case-Control Study in Poland
A study of common inherited variation associated with risk of ovarian cancer, carried out using data and biospeciments from a population-based case-control study of ovarian and endometrial cancer conducted among female residents of Warsaw and Lodz (Poland).
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Prostate, Lung, Colon, and Ovary Prospective Study
A large cohort study of etiologic determinants of cancer carried out within an NCI trial for the evaluation of screening procedures for the early detection of prostate, lung, colon, and ovarian cancer (the PLCO Trial) at 10 U.S. screening centers
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Serum Sex Steroids and Their Metabolites in Relation to Ovarian and Endometrial Cancer
A nested case-control study of endometrial and ovarian cancers assessing the roles of estrogens, estrogen metabolites, androgens, and androgen metabolites in the etiologies of these cancers
Research News
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Daily, Low-dose Aspirin Use May Be Associated with Reduced Ovarian Cancer Risk
Lauren Hurwitz and Britton Trabert utilized extended follow up data on 41,633 women enrolled in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Cancer Screening Trial.
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Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium
Study found that women under the age of 70 who use aspirin (or non-aspirin NSAIDS) daily or almost daily for at least six months have a ~10 percent lower risk of developing ovarian cancer than women who use it infrequently or not at all.
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Across many behaviors, long-term oral contraceptive use lowers risk for ovarian, endometrial cancers
DCEG researchers investigated whether the relationship between oral contraceptive use and risks for ovarian, endometrial, breast, and colorectal cancers change when looking at groups of women who have different health behaviors.