DCEG researchers conduct studies on cancers of the ovary, also known as ovarian cancer. Most ovarian cancers are either epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or malignant germ cell tumors (cancer that begins in egg cells). Selected studies include:
A study to investigate the association of risk factors with molecular changes in the ovaries and endometrium
A prospective study of women who are at increased risk of ovarian cancer either because they or a close relative carry a cancer-causing variation in the BRCA1 or BRCA2 genes, or because they have a strong family history of breast and/or ovarian cancer. This study is closed to patient enrollment but data analysis is ongoing.
A study of common inherited variation associated with risk of ovarian cancer, carried out using data and biospeciments from a population-based case-control study of ovarian and endometrial cancer conducted among female residents of Warsaw and Lodz (Poland).
A nested case-control study of endometrial and ovarian cancers assessing the roles of estrogens, estrogen metabolites, androgens, and androgen metabolites in the etiologies of these cancers
A large cohort study of etiologic determinants of cancer carried out within an NCI trial for the evaluation of screening procedures for the early detection of prostate, lung, colon, and ovarian cancer (the PLCO Trial) at 10 U.S. screening centers