Shanghai Women's Health Study

The Shanghai Women's Health Study (SWHS), a collaborative study by DCEG's Occupational and Environmental Epidemiology Branch (OEEB), Vanderbilt University, and the Shanghai Cancer Institute, is a prospective cohort study of approximately 75,000 Chinese women who were recruited between 1997 and 2000. Members of the cohort have been followed through multiple in-person interviews to obtain information on diet, occupational and environmental exposures, and various lifestyle factors. Information from the follow-ups is linked to vital records and the tumor registry to obtain information on disease.

Special characteristics of the cohort include the following: It is a population-based sample with very high response rates; it is composed of almost entirely never-smokers; and it uses a detailed exposure database that includes tens of thousands of workplace measurements collected over many decades in Shanghai.

Over the years, data and biological samples (blood/buccal cell and urine) collected in the SWHS have been used to evaluate many important etiologic hypotheses and support multiple studies. Most recently, nested case-control molecular epidemiology studies and occupational exposure analyses of lung cancer, brain cancer, and non-Hodgkin lymphoma have been conducted.

For more information, contact Dr. Qing Lan. 

Occupational and Environmental Epidemiology Branch - Research Areas

References

Wong JYY, Cawthon R, Hu W…Lan Q. Alu retroelement copy number and lung cancer risk in the prospective Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Chest 2022. 

Hosgood D, Cai Q, Hua X...Lan Q. Variation in oral microbiome is associated with future risk of lung cancer among never-smokers. Thorax 2021.

Seow WJ, Shu XO, Nicholson JK...Lan Q. Association of untargeted urinary metabolomics and lung cancer risk among never-smokers. JAMA Netw Open 2019.