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Discovering the causes of cancer and the means of prevention

TREAT (TREe-based Association Test)

TREAT (TREe-based Association Test) version 0.0.5 is an R package for detecting complex joint effects in case-control studies. The test statistic is derived from a tree-structure model by recursive partitioning the data. Ultra-fast algorithm is designed to evaluate the significance of association between candidate gene and disease outcome.

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Note: TREAT is designed for 64-bit OS ONLY. Please DO NOT run it on a 32-bit OS, which might give incorrect results.


Zhang H, Wheeler W, Wang ZM, Taylor PR, Yu K. A fast and powerful tree-based association test for detecting complex joint effect in case-control studies Bioinformatics (in press)


Questions? Contact: Dr. Kai Yu (