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STRIDES: Studying Risk and Improving Disparities of Cervical Cancer in Mississippi

Over 500,000 cervical cancers occur every year worldwide, with a disproportionate burden affecting low-resource settings. NCI has a focused research program to understand the etiology of cervical cancer and to accelerate global cervical cancer control. We now understand cervical cancer etiology very well and there are multiple tools available to develop successful screening and management programs.

Despite the widespread availability of cervical cancer screening and management programs in the U.S., over 13,000 women are diagnosed with this malignancy and over 4,000 die from their cancer in the U.S. every year. Mississippi is among the top five states in the nation for cervical cancer incidence and mortality, making the state a critical setting for NCI’s cervical cancer prevention and control efforts.

Reasons for these disproportionately high rates are likely multi-factorial, including:

  • lack of access to cervical cancer screening,
  • delayed or loss-to diagnostic follow-up and treatment,
  • disparities related to race/ethnicity, socioeconomic status, and access to care.

There is a unique opportunity for the NCI to join forces with multiple partners in Mississippi to address these challenges and work towards reducing cervical cancer mortality.

The NCI is partnering with the University of Mississippi Medical Center and the Mississippi State Department of Health to conduct a study to evaluate risk of cervical precancer and to study novel biomarkers in women undergoing cervical cancer screening. The STRIDES Study (STudying Risk to Improve DisparitiES of cervical cancer in Mississippi) is a collaborative, team-science effort involving clinicians, laboratory scientists, epidemiologists, and implementation scientists to address all aspects of cervical cancer prevention and control in Mississippi. STRIDES is a Cancer Moonshot priority.

For more information, contact Nicolas Wentzensen, M.D., Ph.D., or Megan Clarke, Ph.D., M.H.S.

Clinical Epidemiology Unit - Research Areas