DCEG researchers conduct studies on cancers of the cervix, more commonly referred to as cervical cancer. The primary cause of cervical cancer is persistent infection with the human papillomavirus (HPV). Selected studies include:
Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines--the ESCUDDO study (Estudio de Comparacion de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano (VPH)).
A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica
A collaborative study on colposcopic biopsy with aims to study cervical disease on the lesion level, optimize criteria for biopsy placement, and analyze the incremental benefit of taking multiple biopsies
Studies of human papillomavirus (HPV) natural history, genomics and risk assessment that led to advances in screening and clinical management
A study to examine the methylation of the HPV viral genome in relation to risk of cervical intraepithelial neoplasia 3 (CIN 3) and cancer.
A project to interrogate the relationship between sequence changes in the HPV viral genome and carcinogenicity.
A study to develop a cervical cancer risk prediction model incorporating clinical and laboratory covariates.
The Persistence and Progression Cohort (PaP Cohort) is a collaborative study with Kaiser Permanente Northern California to create a repository of specimens for natural history studies, HPV typing, methylation, and HPV variant genomics.
A collaboration with the National Library of Medicine to produce an open source multi-media database for real-time data exploration of cervical images, histology, HPV, and text data from NCI studies of HPV and cervical neoplasia.
A comprehensive evaluation of candidate biomarkers for use in cervical cancer screening and triage.
A study to comprehensively assess biomarkers of risk for progressive cervical neoplasia, and thus develop a new set of biomarkers that can distinguish those at highest risk of cervical cancer from those with benign infection
A study to evaluate a cohort of HIV-infected women using two novel and potentially sustainable, lower-cost tests for accurate screening for cervical cancer
A population-based natural history study of HPV and cervical neoplasia launched with Costa Rican colleagues in 1993.