Research in Action
Mark Schiffman uses molecular epidemiology to predict and prevent cervical cancer.
Article & Video: Taking the Long View
Cervix
DCEG researchers conduct studies on cancers of the cervix, more commonly referred to as cervical cancer. The primary cause of cervical cancer is persistent infection with the human papillomavirus (HPV). Selected studies include:
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Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines—The ESCUDDO* Study
Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines--the ESCUDDO study (Estudio de Comparacion de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano (VPH)).
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HPV Vaccine Trial in Costa Rica
A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica
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Biopsy Study to Improve Detection of Cervical Precancer
A collaborative study on colposcopic biopsy with aims to study cervical disease on the lesion level, optimize criteria for biopsy placement, and analyze the incremental benefit of taking multiple biopsies
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Natural History, Genomics and Human Papillomavirus (HPV) Risk Assessment
Studies of human papillomavirus (HPV) natural history, genomics and risk assessment that led to advances in screening and clinical management
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Methylation of Human Papillomavirus (HPV) and Cervical Cancer Risk
A study to examine the methylation of the HPV viral genome in relation to risk of cervical intraepithelial neoplasia 3 (CIN 3) and cancer.
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Human Papillomavirus (HPV) Viral Genomics Project
A project to interrogate the relationship between sequence changes in the HPV viral genome and carcinogenicity.
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Cervical Cancer Risk Prediction Based on Human Papillomavirus (HPV) Testing
A study to develop a cervical cancer risk prediction model incorporating clinical and laboratory covariates.
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Persistence and Progression Cohort (PaP Cohort)
The Persistence and Progression Cohort (PaP Cohort) is a collaborative study with Kaiser Permanente Northern California to create a repository of specimens for natural history studies, HPV typing, methylation, and HPV variant genomics.
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Cervical Visualization Study
A collaboration with the National Library of Medicine to produce an open source multi-media database for real-time data exploration of cervical images, histology, HPV, and text data from NCI studies of HPV and cervical neoplasia.
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Improvement of Risk-Informed Screening (IRIS)
A comprehensive evaluation of candidate biomarkers for use in cervical cancer screening and triage.
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Study to Understand Cervical Cancer Early Endpoints and Determinants (SUCCEED)
A study to comprehensively assess biomarkers of risk for progressive cervical neoplasia, and thus develop a new set of biomarkers that can distinguish those at highest risk of cervical cancer from those with benign infection
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Cervical Cancer Screening Among HIV-Infected Women in India
A study to evaluate a cohort of HIV-infected women using two novel and potentially sustainable, lower-cost tests for accurate screening for cervical cancer
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Guanacaste HPV Natural History Study
A population-based natural history study of HPV and cervical neoplasia launched with Costa Rican colleagues in 1993.