Esophagus
DCEG researchers conduct studies and participate in consortial activities on cancers of the esophagus, also known as esophageal cancer. Two types of esophageal cancer are squamous cell carcinoma and adenocarcinoma, and Barrett's esophagus is a precursor lesion of esophageal adenocarcinoma. Selected studies and consortia include:
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Barrett Esophagus Early Detection Study
A case-control study of Barrett esophagus and potential biomarkers
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Golestan Cohort Study
A cohort study evaluating the environmental and genetic risk factors for esophageal squamous cell carcinoma in Iran
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Gastric and Esophageal Malignancies in Northern Iran (GEMINI)
A case-control study evaluating environmental and genetic risk factors for esophageal squamous cell carcinoma in Golestan Province, Iran
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Upper Gastrointestinal Cancer Genetic Studies in Shanxi Province, China
Studies initiated to look for major susceptibility genes for upper gastrointestinal cancers and to identify the genetic changes associated with their development
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Nutrition Intervention Trials in Linxian, China
Randomized controlled trials were launched in 1985 to test the effects of multiple vitamin and mineral interventions on total mortality and total and cause-specific cancer mortality in a rural Chinese population
Consortial Activities
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Barrett’s and Esophageal Adenocarcinoma Consortium
An international consortium with epidemiologic studies of Barrett's Esophagus and esophageal adenocarcinoma. Analyses so far have included alcohol consumption, anthropometry, cigarette smoking, excess risk models, gastroesophageal reflux disease, non-steroidal anti-inflammatory drugs, reproductive factors, and genome-wide studies to identify susceptibility loci associated with Barrett’s esophagus and/or adenocarcinomas of the esophagus.
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African Esophageal Cancer Consortium (AfrECC)
The African Esophageal Cancer Consortium (AfrECC) facilitates collaborations to coordinate etiologic and molecular studies of esophageal squamous cell carcinoma in East Africa.