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Liver Cancer Pooling Project

Liver cancer incidence and mortality have been increasing in the United States since 1980. Reasons for the increases are not clear. Known risk factors include chronic infections with hepatitis B virus and hepatitis C virus, excessive consumption of alcohol, certain rare metabolic disorders (e.g., hemochromatosis), diabetes and obesity. Whether these factors explain liver cancer in the U.S. has not been adequately examined. As a result, investigators in DCEG are conducting a liver cancer pooling project among existing U.S. cohorts in order to explore liver cancer etiology in a prospective manner. Cohorts are contributing questionnaire data and serum samples to this effort. As liver cancer remains a rare disease, despite the increasing incidence, additional U.S. cohorts are being sought to participate in this investigation.

For more information, contact Katherine McGlynn.

Metabolic Epidemiology Branch - Research Areas