Investigators collected follow-up data through 2002 for a study of site-specific cancer mortality among tuberculosis (TB) patients treated with artificial lung collapse therapy in Massachusetts TB sanatoria between 1930 and 1950.
Treatment involved frequent chest fluoroscopy examinations, which delivered highly fractionated radiation doses to breast, lung, and other thoracic organs. The estimated mean doses to breast and lung for these patients are 0.74 and 0.84 Gy, respectively.
In earlier analyses, breast cancer but not lung cancer was linked to cumulative radiation dose. Those results are consistent with the other cohort of tuberculosis patients exposed to chest fluoroscopy in Canada. Acquiring new cancer cases, particularly lung cancer, should allow DCEG investigators to conduct a more detailed dose-response analysis and refine risk estimates for fractionated radiation.
For more information, contact Dr. Cari Kitahara.