The R package provides individual risks of lung cancer and lung cancer death based on various published papers: Bach et al., 2003; Spitz et al., 2007; Cassidy et al., 2008 (LLP); Hoggart et al., 2012; Tammemagi et al., 2013; Marcus et al., 2015 (LLPi); Wilson and Weissfeld, 2015 (Pittsburgh); Katki et al., 2016 (LCRAT, LCDRAT, and versions constrained to a few variables); Katki et al., 2018; Cheung et al., 2019 (LYFS-CT).
This package also estimates the Life Years Gained From Screening-CT (LYFS-CT) as per Cheung et al., 2019. It requires the same variables as LCDRAT plus 12 additional comorbidities and the year of patient assessment.
Download Software (v4.1.1)
The Excel tool provides individual risks of lung cancer incidence (LCRAT), lung cancer death (LCDRAT), and life gained from screening with CT (LYFS-CT) based on Katki et al., 2016, and Cheung et al., 2019.
References
- Bach PB, Kattan MW, Thornquist MD, et al. Variations in lung cancer risk among smokers. J Natl Cancer Inst. 2003.
- Spitz MR, Hong WK, Amos CI, et al. A risk model for prediction of lung cancer. J Natl Cancer Inst 2007.
- Cassidy A, Myles JP, van Tongeren M, et al. The LLP risk model: An individual risk prediction model for lung cancer. Br J Cancer. 2008.
- Hoggart C, Brennan P, Tjonneland A, et al. A risk model for lung cancer incidence. Cancer Prev Res. 2012.
- Tammemagi MC, Katki HA, Hocking WG, et al. Selection criteria for lung-cancer screening. N Engl J Med. 2013.
- Marcus MW, Chen Y, Raji OY, Duffy SW, Field JK. LLPi: Liverpool lung project risk prediction model for lung cancer incidence. Cancer Prev Res. 2015.
- Wilson DO, Weissfeld J. A simple model for predicting lung cancer occurrence in a lung cancer screening program: The Pittsburgh predictor. Lung Cancer. 2015.
- Katki HA, Kovalchik SA, Berg CD, Cheung LC, Chaturvedi AK. Development and validation of risk models to select ever-smokers for CT lung cancer screening. JAMA. 2016.
- Katki HA, Kovalchik SA, Petito LC, Cheung LC, Jacobs E, Jemal A, Berg CD, Chaturvedi AK. Implications of nine risk prediction models for selecting ever-smokers for computed tomography lung cancer screening. Ann Intern Med. 2018.
- Cheung LC, Berg CD, Castle PE, Katki HA, Chaturvedi AK. Life-gained-based versus risk-based selection of smokers for lung cancer screening. Ann Intern Med. 2019.