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Discovering the causes of cancer and the means of prevention

Breast Radiology Evaluation and Study of Tissues (BREAST) Stamp Project

Investigators in DCEG are currently collaborating with colleagues in NCI’s Breast Cancer Surveillance Consortium at the University of Vermont, the University of California at San Francisco, and in NCI’s Division of Cancer Control and Population Sciences, on the Breast Radiology Evaluation and Study of Tissues (or “BREAST”) Stamp Project. A total of 466 women ages 40-65 years who were clinically referred to radiologically-guided breast biopsy were enrolled from fall 2007 through summer 2010. The BREAST Stamp Project aims to characterize the radiologic, histologic, molecular, and biochemical features of dense breast tissue and to understand how the microenvironment of dense breasts promotes neoplastic transformation of the breast epithelium. Risk factor data and biological specimens (blood, buccal cells, tissue fluids, and tissue) required to discover mechanisms and biomarkers that link high mammographic density (as measured quantitatively using computerized methods) to breast cancer risk were collected from study participants.

For more information, contact Gretchen Gierach.

Integrative Tumor Epidemiology Branch- Research Areas