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Discovering the causes of cancer and the means of prevention

Human Papillomavirus (HPV) Methylation

Pulling from specimens accumulated in cohort and case-control studies, we are examining the methylation of the HPV viral genome in relation to risk of cervical intraepithelial neoplasia 3 (CIN 3) and cancer. As a general rule for multiple HPV types, increased methylation particularly of CpG sites in the L1 gene is strongly associated with increased risk of CIN 3 and cancer. The goal is to understand the etiologic meaning and possible biomarker utility of viral (and cervical) gene methylation.

For more information, contact Mark Schiffman and Nicolas Wentzensen.

Clinical Genetics Branch - Research Areas