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Discovering the causes of cancer and the means of prevention

Case-Control Study of Renal Cell Cancer among Whites and African Americans in the United States

This population-based case-control study was conducted in the metropolitan areas of Detroit and Chicago in collaboration with Wayne State University and the University of Illinois at Chicago. The aims of this study are to evaluate risk factors for renal cell cancer and examine why rates of this disease are higher among U.S. blacks than whites. Between 2002 and 2007, DCEG investigators interviewed and collected saliva and blood samples from 1,217 cases (856 white, 361 black) and 1,235 controls (712 white, 523 black). Tumor tissue blocks, diagnostic slides, and medical records were also collected from cases. Factors being evaluated include hypertension and other medical conditions, medication use, obesity and weight fluctuation, cigarette smoking, occupational exposures, markers of genetic susceptibility, and several molecular markers in tumor tissue and peripheral blood. Findings to date suggest that black-white differences in hypertension and chronic kidney disease might explain a substantial portion of the racial disparity in kidney cancer incidence.

For more information, contact Dr. Mark Purdue or Dr. Jonathan Hofmann.

Occupational and Environmental Epidemiology Branch - Research Areas