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Leukemia

Leukemia is a type of blood cancer that begins in the bone marrow. Leukemia is characterized by large numbers of abnormal blood cells that are produced and then enter the bloodstream. DCEG researchers are investigating novel, molecular biomarkers for leukemia, as well as clarifying relationships of established risk factors. Selected studies include: 

  • Benzene-Exposed Workers in China

    A binational, multidisciplinary study of Chinese benzene-exposed workers and unexposed workers from more than 700 factories in 12 cities

  • Formaldehyde Exposure and Cancer Risk

    Studies to investigate occupational formaldehyde exposure and cancer risk, including an industrial cohort study of over 25,000 workers, a case-control study of workers in the funeral industry, and a cross-sectional study to quantify leukemia-specific chromosome changes associated with formaldehyde exposure

  • Familial Blood and Lymph Node Cancers Study

    A study of a group of familial blood and lymph node cancers (also called "lymphoproliferative disorders"), including: chronic lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, Waldenström's macroglobulinemia, and multiple myeloma

  • Familial Chronic Lymphocytic Leukemia Study

    A study of families with multiple cases of chronic lymphocytic leukemia, the most common leukemia in adults in the Western Hemisphere and one of a group called "lymphoproliferative disorders"

  • Inherited Bone Marrow Failure Syndromes (IBMFS)

    A study of inherited bone marrow failure syndromes (IBMFS), a group of rare genetic blood disorders that include Fanconi Anemia, Dyskeratosis Congenita, Diamond-Blackfan Anemia, Shwachman-Diamond Syndrome, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia, and Thrombocytopenia Absent Radii.

  • Li-Fraumeni Syndrome Study (LFS)

    A clinical study and multi-institutional collaboration for research on Li-Fraumeni Syndrome (LFS). The NCI has evaluated families with LFS since the syndrome was first recognized in 1969. DCEG is now expanding this research through a clinical study and participation in a multi-institutional collaboration.

  • Study of Childhood Leukemia and Environmental Pesticide and Other Chemical Exposures in California

    A population-based case-control study of childhood leukemia in the San Francisco Bay area and the agricultural Central Valley

cartoon graphic showing Per- and polyfluoroalkyl Substances

In Utero PFAS Exposure and Childhood Leukemia

First study of PFAS levels in pregnancy and risk of leukemia in offspring.
Close up of chemotherapy IV drip in a hospital setting. Chemotherapy for childhood cancer associated with elevated risk of leukemia.

Chemotherapy for Childhood Cancer Associated with Elevated Risk of Leukemia

Risk of therapy-related myelodysplastic syndrome and acute myeloid leukemia after initial chemotherapy for childhood cancer has significantly increased between 1975 and 2015.
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