DCEG investigators are conducting a study to investigate to what extent blood (circulating) concentrations of sex hormones represent concentrations within the prostate. A total of 260 subjects, including African Americans and European Americans, diagnosed with prostate cancer, benign prostatic hyperplasia, or bladder cancer and undergoing prostatectomy were recruited for tissue and blood collection. Hormone levels in prostatic tissue are being measured and compared with serum levels and polymorphisms of hormone-related genes. Levels of androgen receptor and its associated proteins in prostate tissue are being measured directly. In addition, factors such as age, smoking, and body size that might alter serum-tissue correlations are being examined.
For more information, contact Michael Cook.