Biomarkers of Exposure and Effect in Agriculture (BEEA)
Agricultural exposures including pesticides, endotoxins, and diesel exhaust have been associated with risk of various cancers, although the biological mechanisms underlying these associations are generally not well understood. To address this gap, DCEG investigators initiated the Biomarkers of Exposure and Effect in Agriculture (BEEA) study within the Agricultural Health Study, a cohort that includes pesticide applicators in Iowa and North Carolina. Within BEEA, they collected biospecimens (blood, urine, buccal cells, and house dust) and updated information about pesticide use and other agricultural exposures from over 1,600 farmers/pesticide applicators.
The BEEA study biorepository will be a resource for future cross-sectional molecular epidemiologic investigations to elucidate the biological mechanisms underlying associations between agricultural exposures and risk of cancer and other chronic diseases. For example, within BEEA investigators are studying agricultural exposures that might influence the risk of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance, which was previously shown to be in excess in the Agricultural Health Study.
For more information on BEEA, contact Dr. Jonathan Hofmann.