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Discovering the causes of cancer and the means of prevention

Bone Cancer (Osteosarcoma)

DCEG investigators have a major interest in identifying genetic modifiers of risk for osteosarcoma, a primary bone cancer of adolescents and young adults. This work builds upon initial observations by Dr. Sharon Savage in the Bone Disease and Injury Study of Osteosarcoma. Analyses of single nucleotide polymorphisms in osteosarcoma cases and controls found associations between several biologically plausible genes and osteosarcoma risk. Our registry studies of osteosarcoma have further refined the descriptive epidemiology of this disease. Additionally, through an international collaborative effort, we showed strong associations between height at diagnosis and birth weight with osteosarcoma.

In collaboration with the Children’s Oncology Group and multiple international institutions, we are conducting genomic studies to expand our understanding of the genetic contribution to osteosarcoma etiology and outcomes.

Osteosarcoma Study-Related Publications

For more information, contact Lisa Mirabello.

Clinical Genetics Branch - Research Areas