Ewing sarcoma (EWS) is a pediatric bone tumor for which genetic risk factors remain poorly understood. DCEG investigators are studying inherited genetic variation to identify regions in the genome associated with increased risk of EWS by comparing the frequency of genotyped genetic variants between EWS cases and ancestry-matched, cancer-free controls to identify variants more frequently observed in EWS cases. This large (2,000+ cases), international consortium combines previously published data with new EWS cases to perform integrative analyses of newly discovered genetic susceptibility regions to identify local genomic structures and nearby target genes that may be important for EWS risk. The overall goal of the study is to expand our understanding of EWS etiology and provide insight into improved treatment and potentially preventative measures to reduce the overall burden of EWS.
For more information, contact Mitchell Machiela.