Oral Cavity, Larynx, and Pharynx
DCEG researchers conduct studies on cancers of the oral cavity, larynx, and pharynx. The majority of oral cavity and larynx cancers are due to tobacco and alcohol use. Some cancers of the oropharynx, a subsite of the pharynx, are caused by infection with the human papillomavirus (HPV).
Selected studies include:
There is huge variability in risk of precancer and cancer conferred by different HPV types that is poorly explained. HPV type 16 is known to cause half of all cervical cancer cases worldwide, however, the specific reason for its carcinogenicity has been elusive. The HPV Genomics Project is designed to interrogate the relationship between sequence changes in the HPV genome and carcinogenicity.
A study to determine the impact of HPV vaccination in preventing infections in the oral, vulvar, and anal regions