Research in Action
Mark Schiffman uses molecular epidemiology to predict and prevent cervical cancer.
Article & Video: Taking the Long View
Infectious Agents
Viral and bacterial infections are known to cause a number of different malignancies in populations world-wide. DCEG carries out multidisciplinary studies of carefully selected populations in the United States and abroad, with the goal of clarifying the relationship of infectious agents, especially viruses, to human cancer and other conditions. Recent research has concentrated on human retroviruses (HIV-1), with additional studies on human papillomaviruses (HPV), hepatitis viruses, papovaviruses, and human herpesviruses (HHV), especially HHV-8.
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HPV Vaccine Trial in Costa Rica
A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica
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Study of HPV Vaccine Efficacy at Extracervical sites
A study to determine the impact of HPV vaccination in preventing infections in the oral, vulvar, and anal regions
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Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines—The ESCUDDO* Study
Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines--the ESCUDDO study (Estudio de Comparacion de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano (VPH)).
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Anal Precancer and Cancer in HIV-Positive Men (Anal Cancer Screening Study)
A study of anal cancer risk in HIV-positive men who have sex with men
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ASC-US/LSIL Triage Study (ALTS)
A study of the clinical management of low-grade cervical cytologic abnormalities
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Cervical Adenocarcinoma Case-Control Study
A multi-center case-control study of cervical adenocarcinomas and other rare histological forms of cervical cancer
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Study to Understand Cervical Cancer Early Endpoints and Determinants (SUCCEED)
A study to comprehensively assess biomarkers of risk for progressive cervical neoplasia, and thus develop a new set of biomarkers that can distinguish those at highest risk of cervical cancer from those with benign infection
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Biopsy Study to Improve Detection of Cervical Precancer
A collaborative study on colposcopic biopsy with aims to study cervical disease on the lesion level, optimize criteria for biopsy placement, and analyze the incremental benefit of taking multiple biopsies
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Cervical Cancer Screening Among HIV-Infected Women in India
A study to evaluate a cohort of HIV-infected women using two novel and potentially sustainable, lower-cost tests for accurate screening for cervical cancer
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HIV/AIDS Cancer Match, U.S.
HIV/AIDS cancer match study examines cancer risk among people living with HIV infection in the United States.
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Kaposi Sarcoma Molecular Studies
Studies that address unresolved questions on the genomic integrity of Kaposi sarcoma (KS) and whether multiple tumors in individuals are clonal
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Kaposi Sarcoma-associated Herpesvirus in Uganda
Studies of Kaposi sarcoma-associated herpesvirus transmission and prevalence in Uganda
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EBV and Genetics in AIDS NHL
Epstein-Barr virus and genetics in AIDS-related non-Hodgkin lymphoma
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Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM)
A large, multidisciplinary epidemiological effort designed to evaluate environmental and host factors associated with childhood Burkitt lymphoma in sub-Saharan Africa
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EBV-Associated Gastric Cancer
DCEG studies of Epstein-Barr virus (EBV) and gastric cancer
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Lung Cancer and Infectious Agents
DCEG studies of lung cancer and infectious agents, including Chlamydophila pneumonia