Infectious Agents

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Viral and bacterial infections are known to cause a number of different malignancies in populations world-wide. DCEG carries out multidisciplinary studies of carefully selected populations in the United States and abroad, with the goal of clarifying the relationship of infectious agents, especially viruses, to human cancer and other conditions. Recent research has concentrated on human retroviruses (HIV-1), with additional studies on human papillomaviruses (HPV), hepatitis viruses, and papovaviruses.

• Human Papillomavirus
• Human Immunodeficiency Virus (HIV)
• Epstein-Barr Virus (EBV)

Human Papillomavirus (HPV)

• HPV Vaccine Trial in Costa Rica
  A randomized, controlled phase III trial of a vaccine to prevent human papillomavirus (HPV) 16 and 18 infections and their associated cervical lesions in Costa Rica
• Study of HPV Vaccine Efficacy at Extracervical sites
  A study to determine the impact of HPV vaccination in preventing infections in the oral, vulvar, and anal regions
• Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines—The ESCUDDO* Study
  Scientific Evaluation of One or Two Doses of the Bivalent or Nonavalent Prophylactic HPV Vaccines--the ESCUDDO study (Estudio de Comparacion de Una y Dos Dosis de Vacunas Contra el Virus de Papiloma Humano (VPH)).
• Anal Precancer and Cancer in HIV-Positive Men (Anal Cancer Screening Study)
  A study of anal cancer risk in HIV-positive men who have sex with men
• ASC-US/LSIL Triage Study (ALTS)
  A study of the clinical management of low-grade cervical cytologic abnormalities
• Study to Understand Cervical Cancer Early Endpoints and Determinants (SUCCEED)
  A study to comprehensively assess biomarkers of risk for progressive cervical neoplasia, and thus develop a new set of biomarkers that can distinguish those at highest risk of cervical cancer from those with benign infection
• Biopsy Study to Improve Detection of Cervical Precancer
  A collaborative study on colposcopic biopsy with aims to study cervical disease on the lesion level, optimize criteria for biopsy placement, and analyze the incremental benefit of taking multiple biopsies
• Cervical Cancer Screening Among HIV-Infected Women in India
  A study to evaluate a cohort of HIV-infected women using two novel and potentially sustainable, lower-cost tests for accurate screening for cervical cancer
• STRIDES: Studying Risk and Improving Disparities of Cervical Cancer in Mississippi
  The NCI is partnering with the University of Mississippi Medical Center to evaluate risk of cervical precancer and to study novel biomarkers in women undergoing cervical cancer screening.

Human Immunodeficiency Virus (HIV)

• HIV/AIDS Cancer Match Study
  HIV/AIDS cancer match study examines cancer risk among people living with HIV infection in the United States.

Epstein-Barr Virus (EBV)

• EBV-Associated Gastric Cancer
  DCEG studies of Epstein-Barr virus (EBV) and gastric cancer
• EBV and Genetics in AIDS NHL
  Epstein-Barr virus and genetics in AIDS-related non-Hodgkin lymphoma
• EBV Screening for the Early Detection of Nasopharyngeal Carcinoma
  The Epstein-Barr virus (EBV) Screening for the Early Detection of Nasopharyngeal Carcinoma (NPC) in China demonstration project includes a group of approximately 30,000 men and women ages 35-69 recruited into the active screening arm of a community-randomized trial to evaluate the impact of EBV-based antibody screening on NPC mortality rates.
• Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM)
  A large, multidisciplinary epidemiological effort designed to evaluate environmental and host factors associated with childhood Burkitt lymphoma in sub-Saharan Africa