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Discovering the causes of cancer and the means of prevention

Genetic Susceptibility

DCEG researchers actively investigate the role of common and uncommon inherited variations in the genetic code associated with risk of cancer. This work is carried out using biological samples from study participant and techniques like genome-wide association studies, whole genome scans, and new and emerging technologies and methods. Examples of studies include:

Brain

Genetic Susceptibility and Brain Tumors

Study of common genetic variation associated with risk for brain tumors

Breast

Breast Cancer Among Asian Women

A study of breast cancer among Asian populations, including mainland China, Hong Kong, and Malaysia, with the aim of identifying distinct molecular alterations in tumors and adjacent normal tissues, and examining the associations of these molecular changes with risk factors (genetic and environmental), breast tissue composition and density, and breast cancer subtypes.

Breast Cancer Case-Control Study in Poland

A population-based case-control study of breast cancer in Poland that combines state-of-the art techniques of exposure assessment and collection of biological specimens

Breast Cancer Detection Demonstration Project Follow-up Study

A follow-up study of women who were participants in the Breast Cancer Detection Demonstration Project

Melanoma

Familial Melanoma Studies

A search for new genes associated with melanoma susceptibility in melanoma-prone families

Genetic and Molecular Epidemiology Studies of Melanoma in Italy

A case-control study in Italy to study the role of pigmentation and other host factors in the etiology of melanoma

Ovary and Endometrium

Ovarian and Endometrial Cancer Case-Control Study in Poland

A study of common inherited variation associated with risk of ovarian cancer, carried out using data and biospeciments from a population-based case-control study of ovarian and endometrial cancer conducted among female residents of Warsaw and Lodz (Poland).

Upper Gastrointestinal Tract

Upper Gastrointestinal Cancer Genetic Studies in Shanxi Province, China

Studies initiated to look for major susceptibility genes for upper gastrointestinal cancers and to identify the genetic changes associated with their development