Altered immunity and chronic inflammation appear to play a key role in the etiology of several malignancies. DCEG researchers investigate the role of the immune system in cancer etiology, measuring immune response as part of the host response to exogenous exposures. For example, we are closely examining the substantially elevated cancer risk among solid organ transplant recipients who receive long-term immunosuppressant medications to prevent organ rejection. We are also considering how chronic inflammation from infection is related to cancer risk, as demonstrated by H. pylori with gastric cancer and periodontal hygiene with oral and esophageal cancers.
Examples of studies involving immunologic factors include:
HIV/AIDS cancer match study examines cancer risk among people living with HIV infection in the United States.
A collaboration among NCI and extramural investigators, established by DCEG in 2006, that utilizes data and biospecimens from 18 completed and ongoing case series and observational studies of gastric cancer to replicate and extend findings from previous studies hindered by small numbers of EBV-positive cases, and to stimulate multidisciplinary research in this area.
Study of the etiology of cancer among solid organ transplant recipients, using state and regional cancer registries and the U.S. registry of transplant recipients
This research area focuses on studies of identifying predictive biomarkers of clinical outcomes in patients receiving allogeneic hematopoietic cell transplantation (HCT).