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Legend for Fig 1: Hereditary Multicancer Syndrome

, by DCEG Staff

Figure 1. Pedigree of Family A from the first paper documenting the constellation of tumors in what would later come to be known as Li-Fraumeni syndrome.  This family developed a remarkable combination of multiple cancers in children and young adults, including soft tissue sarcomas and breast cancer. The pedigree shows the first affected individual in the family (the proband) in the fifth generation.

First generation: 1-1 deceased male (no cancer) married to 1-2 deceased female (cancer by history, no confirmation).

Second generation: Children of 1-1 and 1-2:  2-1 deceased female (cancer by history, no confirmation), 2-2 deceased female (breast cancer), 2-3  deceased female (cancer by history, no confirmation).

Third generation: Children of 2-1: 3-1 male (other malignant neoplasm), 3-2 female (no cancer), 3-3 deceased male (other malignant neoplasm). Children of 2-3:  3-4 deceased male (other malignant neoplasm), 3-5 deceased female (breast cancer).

Fourth generation: Children of 3-1: 4-1 and 4-2 (males, no cancer), 4-3 deceased male (other malignant neoplasm) married to 4-4 (female, no cancer). Children of 3-2: 4-5 deceased male (no cancer), 4-6 male (no cancer). Children of 3-3: 4-7 female (no cancer), 4-8 female (breast cancer), 4-9 deceased female (other malignant neoplasm). Children of 3-4: 4-10 male (no cancer), 4-11 female (no cancer). Child of 3-5: 4-12 deceased female (soft tissue sarcoma).

Fifth generation: Child of 4-3 and 4-4: 5-1 male proband (soft tissue sarcoma). Children of 4-6: 5-2 female (no cancer), 5-3 male (no cancer). Children of 4-7: 5-4 and 5-5 (females, no cancer), 5-6 male (no cancer). Children of 4-8: 5-7 deceased male (soft tissue sarcoma), 5-8 male (no cancer), 5-9 and 5-10 (females, no cancer). Child of 4-10: 5-11 female (no cancer). Child of 4-11: 5-12 male (no cancer). Child of 4-12: 5-13 male (no cancer).