A new study has found that people who engage in three to five times the recommended minimum level of leisure-time physical activity derive the greatest benefit in terms of mortality reduction when compared with people who do not engage in leisure-time physical activity. The 2008 Physical Activity Guidelines for Americans, developed by the Department of Health and Human Services’ Physical Activity Guidelines Advisory Committee, recommend a minimum of 2.5 hours of moderate-intensity exercise per week or 1.25 hours of vigorous aerobic activity, but more activity is encouraged for additional health benefits. Before this study, experts did not know how much additional health benefit might accrue for those doing more exercise. This study confirms that much of the mortality benefit is realized by meeting the minimum recommended levels of physical activity and describes the increased mortality benefit associated with higher levels of physical activity. The study appeared online April 6, 2015, in JAMA Internal Medicine. Read more in the full NCI News Note.