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Discovering the causes of cancer and the means of prevention

Normal Tissue Dose Estimates for Patients Undergoing Nuclear Medicine Procedures (NCINM)

Therapeutic Radiation Dosimetry

DCEG investigators in the Radiation Epidemiology Branch (REB) develop dosimetry methods for patients undergoing therapeutic nuclear medicine procedures, in which a radiative substance (radionuclide) is introduced into the body either intravenously or orally, and that substance emits ionizing radiation within a small area inside the body. Dosimetry for nuclear medicine requires biokinetic models for given radionuclides and organ dose coefficients, which convert radionuclide uptake to absorbed dose.

REB investigators are developing different biokinetic models specific to epidemiological study cohorts and a library of dose coefficients by using Monte Carlo radiation transport techniques combined with computational human phantoms. By using comprehensive dose coefficients coupled with an International Commission on Radiological Protection (ICRP) reference biokinetic model, REB investigators are developing a user-friendly computer program, titled National Cancer Institute dosimetry system for Nuclear Medicine (NCINM). The methods have been used for dose estimates to the thyroid, active bone marrow, and other organs for a cohort of 35,593 hyperthyroid patients. The dose estimates will be used for dose-response risk assessment in the extended follow-up of cancer mortality risks among patients with hyperthyroidism treated with 131I.

Schematic representation of the iodine biokinetic model for hyperthyroid patients

Based on Melo D, et al. Radiation Research 2015.

For more information, contact Dr. Choonsik Lee.

Radiation Epidemiology Branch - Research Areas