The Division maintains a broad-ranging, multi-faceted program of descriptive epidemiological studies utilizing a variety of methodological approaches to identify novel risk factors, evaluate tumor heterogeneity, describe current and future trends of common and rare malignancies, and project risk for second primary cancers.
To identify novel carcinogenic exposures our investigators utilize the NCI Geoviewer tool, a visualization mapping tool, to characterize the geographic distribution of cancer as well as differences by race and ethnicity.
In order to take advantage of emerging molecular, genetic, hormonal, and viral markers that influence cancer treatment and prognosis, DCEG investigators are integrating pathology report information into descriptive studies and cancer registries. This effort dovetails with the broader Division program on tumor profiling in relation to cancer etiology.
Large databases linked to cancer registries allow DCEG investigators to assess influence of cancer risk factors on population-level incidence rates. Linked studies include the HIV/AIDS Cancer Match Study, the Transplant Cancer Match Study, and SEER-Medicare.
DCEG investigators have developed sophisticated biostatistical models and analytic tools to help explain changes in cancer incidence and mortality trends over time. An example is the Age-Period-Cohort (APC) tool, designed to enable researchers to disentangle the interactive effects of age-related biology, calendar-period effects (e.g., screening), and birth-cohort exposures from one generation to the next.